Antihyperglycemic Activity of Oil Palm Elaeis guineensis Fruit Extract on Streptozotocin-induced Diabetic Rats

Authors

  • Faez Sharif International Islamic University Malaysia
  • Muhajir Hamid Universiti Putra Malaysia
  • Amin Ismail Universiti Putra Malaysia
  • Zainah Adam Malaysian Nuclear Agency

Keywords:

Elaeis guineensis, oil palm fruit extract, blood glucose level, hypoglycaemic, antihyperglycemic

Abstract

Hypoglycaemic and antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on normal and Streptozotocin-induced diabetic rats was studied. The oil palm fruit extract (OPF) were administered orally at different concentrations (100, 200 and 500 mg kg-1 b.w.) in fasting and post-prandial rats. Hypoglycaemia was not observed in the group of normal rats treated with OPF. In fasting rats, OPF (500 mg kg-1 b.w.) has caused the blood glucose level (BGL) to reduce significantly. For post-prandial diabetic rats, the antihyperglycemic activity was observed after OPF treatment at concentrations 200 and 500 mg kg-1. Chronic OPF treatments (for 28 days) had increased the diabetic rat’s body weight and reduced BGL as well as improved plasma insulin secretion. The result of this study suggests E. guineensis palm fruit extract show evidence of antihyperglycemic properties from the reduction of the BGL in diabetic rats. DOI : http://dx.doi.org/10.17576/JSKM-2015-1302-04

Author Biographies

Faez Sharif, International Islamic University Malaysia

Department of BiotechnologyKulliyah of Science

Muhajir Hamid, Universiti Putra Malaysia

Department of MicrobiologyFaculty of Biotechnology and Biomolecular Sciences

Amin Ismail, Universiti Putra Malaysia

Department of Nutrition and DieteticsFaculty of Medicine and Health Sciences

Zainah Adam, Malaysian Nuclear Agency

Medical Technology Division

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Published

2015-06-30

Issue

Vol. 13 No. 2 (2015)

Section

Articles

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