Antihyperglycemic and Glucose Tolerance Activity of Ficus deltoidea Ethanolic Extract in Diabetic Rats

Authors

  • Muhajir Hamid Universiti Putra Malaysia
  • Amin Ismail Universiti Putra Malaysia
  • Zainah Adam Malaysian Nuclear Agency
  • Shafii Khamis Malaysian Nuclear Agency
  • Norazizah Marsidi Malaysian Nuclear Agency

Keywords:

Ficus deltoidea, diabetes, antihyperglycemic, postprandial, glucose tolerance

Abstract

Ficus deltoidea or Mas cotek is one of the common medicinal plants used in Malaysia has been claimed to have antidiabetic activity. However, scientific evidence to confirm its efficacy is still lacking. Thus, the present study was undertaken to evaluate the potential of ethanolic extract of Ficus deltoidea to reduce hyperglycaemia in streptozotocininduced diabetic rats at different prandial state. The results showed that, ethanolic extract of Ficus deltoidea significantly reduced fasting and postprandial hyperglycemia particularly after 4 and 6 hours of extract administration. Likewise, glucose tolerance activity was significantly improved in the presence of Ficus deltoidea ethanolic extract at a low dose, 100 mg/kg. It is suggested that ethanolic extract of Ficus deltoidea at particular doses, possess fasting and postprandial antihyperglycemic activity as well as glucose tolerance activity in streptozotocin-induced diabetic rats.

Author Biographies

Muhajir Hamid, Universiti Putra Malaysia

Department of MicrobiologyFaculty of Biotechnology and Biomolecular Sciences

Amin Ismail, Universiti Putra Malaysia

Department of Nutrition and DieteticsFaculty of Medicine and Health Sciences

Zainah Adam, Malaysian Nuclear Agency

Medical Technology Division

Shafii Khamis, Malaysian Nuclear Agency

Medical Technology Division

Norazizah Marsidi, Malaysian Nuclear Agency

Medical Technology Division

Downloads

Published

2010-06-30

Issue

Vol. 8 No. 1 (2010)

Section

Articles

License

It is a condition of publication in the Journal that authors assign copyright to the Penerbit, Universiti Kebangsaan Malaysia, using the form available on the Copyright Assignment Form page. This ensures that requests from third parties to reproduce articles are handled efficiently and consistently and will also allow the article to be as widely disseminated as possible. In assigning copyright, authors may use their own material in other publications provided that the Journal is acknowledged as the original place of publication, and Penerbit Universiti Kebangsaan Malaysia is notified in writing and in advance.

Our journal offers an open access articles, which is under the Creative Common license type : Attribution-NonCommercial-ShareAlike (CC BY-NC-SA)