Sleep Deprivation Models in Rodents

Abstract

Sleep deprivation has been identified as a risk factor for various diseases. Number of patients suffering from sleep deprivation is increasing daily, subsequently, increasing the risk to develop various diseases including cardiovascular disease. However, there is a limitation to elucidate the pathophysiological changes following sleep deprivation in human. Thus, the need arises for sleep deprivation models using animal, which will serve the purpose of understanding the disease in a better way. Several techniques have been developed to model sleep deprivation in animals, including the inverted flower pot and multiple platforms techniques. Genetic and environmental factors, cost, infrastructure, and animal life spans are some of the factors need to be considered when choosing a particular model. Besides, when studying sleep deprivation, tissue samples like peripheral blood, brain samples and aorta are used to elucidate the underlying mechanisms of a particular disease. Currently, more than ninety percent of all laboratory animal experiments are conducted in rats and mice. This review article focuses on sleep deprivation models in Rodents, which are generally used in research labs. The article also tries to evaluate the advantages and disadvantages of each of the technique discussed, also gives guidance toward the sleep deprivation model and helps researchers in deciding a particular model for their own purpose.

DOI : http://dx.doi.org/10.17576/JSKM-2021-1902-04